Laboratory Services
Sirolimus, Whole Blood
Print this pageUpdated Test Information:
| Test Description |
Sirolimus, Whole Blood
|
|
|---|---|---|
| Synonym(s) |
Rapamune, Rapamycin, Sirol, UOW2750 |
|
| Test ID |
SIROLG
|
|
| General Information |
The concentration of sirolimus in whole blood is determined by liquid chromatography-tandem mass spectrometry after protein precipitation. The reportable range is 1.0 to 700.0 ng/mL with imprecision of less than 11 %CV. |
|
| Container Type |
3 mL blood in a Lavender top tube. Trough specimen preferred. |
|
| Specimen Type |
Whole Blood |
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| Specimen Requirements |
Entire Sample |
|
| Specimen Collection / Processing Instructions |
Refrigerate whole blood, do not centrifuge. Frozen sample acceptable - Do not repeat freeze-thaw cycle |
|
| Minimum Sample Volume |
1.5 mL whole blood for 3 mL Lavender Liquid EDTA (K3 EDTA); 0.5 mL whole blood for 3 mL Lavender Dry EDTA (K2 EDTA) |
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| Stability |
Refrigerate whole blood 5 days. Frozen sample acceptable - Do not repeat freeze-thaw cycle |
|
| Department (code) |
Chemistry, University (CHU) |
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| Methodology |
Whole blood protein precipitation. Analysis by liquid chromatography - tandem mass spectrometry. |
|
| Estimated TAT |
1 Day |
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| Testing Schedule |
Daily |
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| Test Includes |
Code Name |
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| CPT Code(s) |
80195 |
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| Reference Range |
Whole blood trough Sirolimus concentrations of 5 - 15 ng/mL are effective in reducing the incidence of acute rejection in renal transplant patients when Sirolimus is used as part of a combined immunosuppressive regimen. |
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| STAT Orderable (Y/N) |
No |
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| Performing Lab |
UW |
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| LOINC Code(s) |
