Factor II Activity

Factor 2, UOW1281

This test is NOT for Factor II Mutation, Factor II DNA or Prothrombin DNA. For Factor II Mutation or Factor II DNA, see: PRODS

Factor II (2) activity is used for diagnosing rare congenital factor II deficiency, investigation of prolonged prothrombin time and evaluating acquired deficiency associated with liver disease or vitamin K dependent factor deficiency. Occasionally, prolonged Prothrombin Time and decreased Factor 2 activity can be seen in patients with lupus anticoagulants or antiphospholipid antibodies with specificity for prothrombin (factor II).

3 mL or 5 mL Light Blue Citrate Tube

Blood

Entire Specimen

MUST PROCESS WITH 4 HOURS OF COLLECTION
Platelet poor Coag Citrate Specimen processing:
1. Gently invert tube 2-3 times prior to placing in Centrifuge
2. Centrifuge Citrate whole blood at 4500 rpm for 10 minutes
3. Carefully pipette plasma, avoiding the platelet/buffy coat into a plastic vial
4. Centrifuge plasma at 4500 rpm for 10 minutes
5. Pipette the plasma to a plastic vial, leaving the bottom 0.25 mL undisturbed
6. Freeze plasma immediately and transport frozen. 

1mL

Patients on bivalirudin (Angiomax), dabigatran (Pradaxa), argatroban (Novastan), rivaroxaban (Xarelto), apixaban (Eliquis), and edoxaban (Savaysa) may show prolonged clotting times. This may cause an under- estimation of the factor concentrations.

Coagulation (COAG)

Stago STA Clottable Factor assay

Report by end of next business day

Monday - Friday

85210

                                 Units: %
         Female                                               Male
Age                 Range                 Age                  Range
0-29d             33-115             0-29d              33-115
1m-2m          34-115            1m-2m             34-115
3m-5m          45-115            3m-5m             45-115
6m-                  50-115            6m-                    50-115

No

UW

3289-6